Funded Projects

The PCC has supported world-class research since 2008, investing more than $35.6 M to drive novel science. Research and grant-making are the foundation of the PCC and are the focus of everyday business activity. PCC-supported research contributes to a movement in addressing doping’s root causes and ultimately decreasing the use of performance-enhancing drugs by all participants in all sports at all levels of play.

Funded PCC projects represent proposals from 23 different countries and three continents. More than 100 principle investigators have been awarded grants to advance anti-doping knowledge through more than 250 unique research projects. Projects which showcase alignment with the PCC research priorities are given funding precedence.

Please contact us if you have questions regarding individual projects listed here.

Fellowships

Funded: 2022

Fellow:
Dr. Jenna Goodrum, Sports Medicine Research and Testing Laboratory (SMRTL)

Mentor:
Dr. Goeff Miller, SMRTL

Research Title: 

Biotin as a masking agent for hCG

Funded: 2022

Fellow:
Dr. Sara Amalie Solheim, Oslo University Hospital and the Norwegian School of Sport Sciences

Mentor:
Dr. Yvette Dehnes, Laboratory and APMU Director, Norwegian Doping Control Laboratory

Research Title:

Further development of blood testing: ABP, deterrence and virtual testing

Funded: 2022

Fellow:
Dr. Huu Hien Huynh, University of Washington

Mentor:
Dr. Andrew Hoofnagle; University of Washington

Research Title:

Quantification of type III procollagen fragments in capillary blood

Funded: 2019

Fellow:
Dr. Federico Ponzetto, University of Turin

Mentor:
Professor Ezio Ghigo; University of Turin

Research Title:

Implementation of a blood steroidal module in the framework of the athlete

Research Summary:

The research project entitled “Implementation of a blood steroidal module in the framework of the Athlete Biological Passport” and carried out at the Department of Medical Sciences of the University of Turin, aimed at providing a robust analytical tool for investigating the variations of Blood Steroid Profile. During the 2 years of the project a novel LC-MS/MS method for the quantification of 27endogenous steroids, including major circulating hormones as well as a wide panel of androgens’ phase II metabolites, was developed and validated according to WADA guidelines. This method was then used for calculating preliminary reference intervals of target analytes, some of which were never reported to date, analyzing serum samples collected from healthy volunteers accessing to the Blood Bank of Turin University Hospital. Furthermore, the potential impact of circadian rhythm and physical exercise on Blood Steroid Profile markers was investigated thanks to the analysis of serum/plasma samples collected during two dedicated clinical studies involving 19 healthy male volunteers and 31professional football players. The outcomes of these studies , beside proving the usefulness of the developed analytical platform for gathering additional information on steroid metabolism, useful for the introduction of blood steroid profiling in anti-doping context, highlighted that serum concentrations of testosterone(T) and dihydrotestosterone (DHT)as well as of androgens phase II metabolites are not significantly perturbated by diurnal variations linked to circadian rhythm and by a moderate physical exercise such as a football training session. These results strongly support the introduction of such markers in the future implementation of Blood Steroid Profile for doping control purposes, remarking the utility of monitoring not only T and DHT but also more concentrated phase II metabolites such as etiocholanolone glucuronide, androsterone glucuronide, epiandrosterone sulphate and androsterone sulphate. During the performed studies it was also observed that the administration of 5α-reductase inhibitors (e.g., Finasteride) could have a strong impact on target markers, stressing the need of dedicated study for better characterizing steroid response to such intake. Finally, with the aim of suggesting an easier sample collection procedure for Blood Steroid Profile, a further analytical method for the measurement of most concentrated steroidal compounds from Volumetric Absorptive Micro-Sampling (VAMS) was developed, validated and applied to assess the medium-term stability of target analytes in blood micro-matrices. The promising results obtained in this proof-of-concept study, underlining the stability of VAMS samples up to 100 days at-80°C,opened the way to the use of such technology for simplifying blood sample collection, storage and transportation in the future studies that are needed to fully characterize the perturbations of endogenous and exogenous potential confounding factors on Blood Steroid Profile. Although the advances obtained thank to the present projects, there is still lack of population studies for the definition of reference intervals in elite athletes’ populations as well as for the assessment of long-term intra-individual variation of most promising serum markers of EAAS doping. These topics could represent the challenge for future research project in the field of steroid analysis in anti-doping context.

Funded: 2018

Fellow:
Dr. Scott Lacombe, Dell Pediatric Research Institute, University of Texas at Austin.

Mentor:
Dr. Herbert Tobias; Dell Pediatric Institute, University of Texas at Austin
Dr. Tom Brenna; Dell Pediatric Institute, University of Texas at Austin

Research Title:

Validation of ARC Catalytic Combustion Reactors for Fast GCC-IRMS and
GC×GCC-IRMS

Funded: 2018

Fellow:
Dr. Jacob Bejder, University of Copenhagen

Mentor:
Dr. Nikolai Nordsborg, University of Copenhagen

Research Title:

Improving detection of erythropoiesis stimulating agents and glucocorticoids

Funded: 2018

Fellow:
Dr. Danielle Moncrieffe, King’s College London Drug Control Centre

Mentor:
Prof. David Cowan; King’s College London Drug Control Centre

Research Title:

Improving sample preparation for the quantification of low level proteins in blood

Funded: 2018

Fellow:
Dr. Laura Lewis; Australian Catholic University

Mentor:
Dr. Daniel Eichner, SMRTL

Research Title:

Influence of Relative Energy Deficiency in Sport (RED-S) on the Athlete Biological Passport

Funded: 2016

Fellow:
Dr. Liying Jiang; King’s College London Drug Control Centre

Mentor:
Dr. David Cowan; King’s College London Drug Control Centre

Research Title:

Strategy for cost reduction in doping test using UPLC-ESPI-TOFMS for urine and DESI-QTOFMS for DBS

Funded: 2014

Fellow:
Dr. Geoff Miller; Sports Medicine Research and Testing Laboratory (SMRTL)

Mentor:
Dr. Daniel Eichner; Sports Medicine Research and Testing Laboratory (SMRTL)

Research Title:

Assessing hydration status through evaluation of albumin osmolality and lactate for the ABP

Micro-Grants