Funded Projects
The PCC has supported world-class research since 2008, investing more than $26 M to drive novel science. Research and grant-making are the foundation of the PCC and are the focus of everyday business activity. PCC-supported research contributes to a movement in addressing doping’s root causes and ultimately decreasing the use of performance-enhancing drugs by all participants in all sports at all levels of play.
Funded PCC projects represent proposals from 17 different countries and three continents. Nearly 90 principle investigators have been awarded grants to advance anti-doping knowledge through more than 100 unique research projects. Projects which showcase alignment with the PCC research priorities are given funding precedence.
Please contact us if you have questions regarding individual projects listed here.
Fellowships
In Progress
Funded: 2018
Fellow:
Dr. Scott Lacombe, University of Toronto, Faculty of Medicine, Dept. of Nutritional Sciences
Mentor:
Dr. Herbert Tobias; Dell Pediatric Institute, University of Texas at Austin
Dr. Tom Brenna; Dell Pediatric Institute, University of Texas at Austin
Research Title:
Validation of ARC Catalytic Combustion Reactors for Fast GCC-IRMS and
GC×GCC-IRMS
In Progress
Funded: 2018
Fellow:
Dr. Jacob Bejder, University of Copenhagen
Mentor:
Dr. Nikolai Nordsborg, University of Copenhagen
Research Title:
Improving detection of erythropoiesis stimulating agents and glucocorticoids
In Progress
Funded: 2018
Fellow:
Dr. Danielle Moncrieffe, King’s College London Drug Control Centre
Mentor:
Prof. David Cowan; King’s College London Drug Control Centre
Research Title:
Improving sample preparation for the quantification of low level proteins in blood
In Progress
Funded: 2018
Fellow:
Dr. Laura Lewis; Australian Catholic University
Mentor:
Dr. Daniel Eichner, SMRTL
Research Title:
Influence of Relative Energy Deficiency in Sport (RED-S) on the Athlete Biological Passport
Complete.
Funded: 2016
Fellow:
Dr. Liying Jiang; King’s College London Drug Control Centre
Mentor:
Dr. David Cowan; King’s College London Drug Control Centre
Research Title:
Strategy for cost reduction in doping test using UPLC-ESPI-TOFMS for urine and DESI-QTOFMS for DBS
Complete.
Following completion of his fellowship, Dr. Geoff Miller accepted a full time position at SMRTL as Research & Laboratory Manager.
Funded: 2014
Fellow:
Dr. Geoff Miller; Sports Medicine Research and Testing Laboratory (SMRTL)
Mentor:
Dr. Daniel Eichner; Sports Medicine Research and Testing Laboratory (SMRTL)
Research Title:
Assessing hydration status through evaluation of albumin osmolality and lactate for the ABP
Publications:
American Academy of Physical Medicine and Rehabilitation: The Anti-Doping Movement
Drug Testing and Analysis: Intranasal delivery of Natesto testosterone gel and its effects on doping markers
Presentations:
Miller G, Teramoto M, Cushman D, Eichner D. Assessing Dehydration in the Context of the
Biological Passport. 34th Cologne Workshop on Dope Analysis; Cologne, Germany. February 2016.
Nair V, Miller G, Morrison S, Summers M, Willick S, Eichner D. Intranasal Delivery of Natesto
Testosterone Gel and Its Effects on Doping Markers. 34th Cologne Workshop on Dope Analysis;
Cologne, Germany. February 2016.
Miller, G. The next generation of anti-doping: PCC Fellowship. Partnership for Clean Competition Conference; New York, NY, April 2017.
Funded: 2012
Fellow:
Dr. Bryan Kelly; Sports Medicine Research and Testing Laboratory (SMRTL)
Mentor:
Dr. Daniel Eichner; Sports Medicine Research and Testing Laboratory (SMRTL)
Micro-Grants
Funded: 2016
Principle Investigator:
Dr. Mario Thevis; German Sport University Cologne
Publication:
Rapid Communications in Mass Spectrometry: Expanding Analytical Options in Sports Drug Testing: Mass Spectrometric Detection of Prohibited Substances in Exhaled Breath
Funded: 2016
Principle Investigator:
Dr. Mario Thevis; German Sport University Cologne
Publications:
International Journal of Sports Medicine: Analyses of Meldonium (Mildronate) from Blood, Dried Blood Spots (DBS), and urine Suggest Drug Incorporation into Erythrocytes.
Analytical and Bioanalytical Chemistry: Qualitative identification of growth hormone-releasing hormones in human plasma by means of immunoaffinity purification and LC-HRMS/MS
Funded: 2014
Principle Investigator:
Dr. Pauline Rudd; National Institute for Bioprocessing Research and Training (NIBRT)
Funded: 2014
Principle Investigator:
Dr. Mario Thevis; German Sport University Cologne
Publications:
Drug Testing & Analysis: Mildronate (Meldonium) in professional sports – monitoring doping control urine samples using hydrophilic interaction liquid chromatography – high resolution/high accuracy mass spectrometry
International Journal of Sports Medicine: Analyses of Meldonium (Mildronate) from Blood, Dried Blood Spots (DBS), and Urine Suggest Drug Incorporation into Erythrocytes
Funded: 2014
Principle Investigator:
Dr. Daniel Eichner; Sports Medicine Research and Testing Laboratory (SMRTL)
Funded: 2016
Principle Investigator:
Dr. Daniel Eichner; Sports Medicine Research and Testing Laboratory (SMRTL)
Complete
Funded: 2016
Principle Investigator:
Professor David Handelsman; ANZAC Research Institute
Publication:
Funded: 2016
Principle Investigator:
Dr. Daniel Eichner; Sports Medicine Research and Testing Laboratory (SMRTL)
Presentations:
Cox, HD, Eichner, D. Targeted quantification of blood cell marker proteins in dried blood spots for the detection of blood doping practices in sport. June 2015. 63rd Meeting of the American Society for Mass Spectrometry. St. Louis, MO.
Cox, HD, Eichner, D. Preliminary evaluation of a novel dried blood spot-based methodology for the detection of blood doping practices in sport. September 2014. USADA Science Symposium. Phoenix, AZ.
Cox, HD, Hughes, CM, Eichner, D. Method to detect blood doping practices in sport through the measurement of reticulocytes in dried blood spots by LC-MS/MS. June 2014. 62nd Meeting of the American Society for Mass Spectrometry. Baltimare, MD.
Funded: 2016
Principle Investigator:
Dr. Lena Ekstrom; Karolinska Instituet
Presentations:
Estrom, L. Testosterone Codeine Study. 35th Manfred Donike Workshop on Dope Analysis. 2017, Cologne, Germany.
Funded: 2016
Principle Investigator:
Prof. Dr. Maria Kristina Parr; Freie Universitat Berlin
Funded: 2016
Principle Investigator:
Dr. Jack Henion; Q2 Solutions
Presentations:
Henion, J. Do DBS and DPS Micro Sampling Techniques have a place in the Clinical Laboratory? MSACL 2016 9th Annual Conference & Exhibits, Jan 22 – 26, Palm Springs, CA, 2017
Henion, J. The Analytical Potential of a Compact Mass Spectrometer (CMS) for the Analysis of Cannabis-Related Samples for Composition and Adulteration. Pittcon Conference and Expo in Chicago, Illinois, 2017 March 5 – 9 .
Henion, J. Alternative Matrices: Dried Plasma Spots. Partnership for Clean Competition Conference. New York, NY, 2017
Funded: 2017
Principle Investigator:
Dr. Robert Chapman; Indiana University
Funded: 2016
Principle Investigator:
Dr. Herb Tobias; Dell Pediatric Research Institute
Funded: 2017
Principle Investigator:
Dr. Pozo Mendoza; IMIM: Institut Hospital del Mar d’Investigacions Mèdiques
Heme Triggered Immune Responses and Redox Pathways as Targets to Detect Autologous Blood Transfusion
Funded: 2017
Principle Investigator:
Dr. Mariana Renovato Martins; Instituto Federal do Rio de Janeiro
Funded: 2017
Principle Investigator:
Dr. Robert Chapman, Indiana University
In Progress
Funded: 2018
Principle Investigator:
Dr. James Hopker, University of Kent
In Progress
Funded: 2018
Principle Investigator:
Dr. G. Reverter Fundació, IMIM
In Progress
Funded: 2018
Principle Investigator:
Dr. Malcolm McLeod, Australian National University
Complete.
Funded: 2019
Principle Investigator:
Dr. Daniel Eichner; Sports Medicine Research and Testing Laboratory (SMRTL)
Publications:
Media: Summer 2019 Newsletter
In Progress.
Funded: 2019
Principle Investigator:
Dr. Yvette Dehnes, Norwegian Doping Control Laboratory
Working Groups
Principle Investigators:
Dr. Mario Thevis; German Sport University Cologne
Dr. Daniel Eichner; Sports Medicine Research and Testing Laboratory (SMRTL)
Dr. David Cowan; King’s College London Drug Control Centre
Dr. Anthony Butch; UCLA Olympic Analytical Laboratory
Dr. Andy Hoofnagle; University of Washington
Publications:
Clinical Chemistry: Interlaboratory agreement of insulin-like growth factor 1 concentrations measured by mass spectrometry
Bioanalysis: Sensitive quantification of IGF-1 and its synthetic analogs in dried blood spots
Drug Testing & Analysis: The development of decision limits for the GH-2000 detection methodology using additional insulin-like growth factor-I and amino-terminal pro-peptide of type III collagen assays
Clinical Chemistry: Immunoextraction-Tandem Mass Spectrometry Method for Measuring Intact Human Chorionic Gonadotropin, Free β-Subunit, and β-Subunit Core Fragment in Urine
Principle Investigators:
Dr. Marilyn Huestis; National Institute on Drug Abuse (NIH)
Dr. Daniel Eichner; Sports Medicine Research and Testing Laboratory (SMRTL)
Principle Investigator:
Dr. Marilyn Huestis; National Institute on Drug Abuse (NIH)
Publications:
Drug & Alchohol Dependence: Pharmacodynamic effects and relationships to plasma and oral fluid pharmacokinetics after intravenous cocaine administration.
Drug Testing & Analysis: Cocaine and benzoylecgonine oral fluid on-site screening and confirmation.
Forensic Science International: Oral fluid cocaine and benzoylecgonine concentrations following controlled intravenous cocaine administration.
Pending Terms & Conditions
Principle Investigator:
Dr. John Higgins; Massachusetts General Hospital
Dr. Nikolai Nordsborg; University of Copenhagen
Dr. Jakob Bejder; University of Copenhagen
Dr. Daniel Eichner, SMRTL
Dr. James Cox, University of Utah
Dr. Merav Socolovsky, U Mass Medical School
Dr. Maziyar Baran Pouyan, University of Pittsburgh Medical School
Dr. John Phillips, University of Utah
Dr. Steve Elliott, PCC Scientific Advisory Board
Dr. Mike Sawka, PCC Scientific Advisory Board
Center of Excellence (Lab Equipment) Grants
Principle Investigators:
Dr. Daniel Eichner; Sports Medicine Research and Testing Laboratory (SMRTL)
Dr. Anthony Butch; UCLA Olympic Analytical Laboratory
Lab Managers can apply for COE grants via regular PCC grant processes.
Principle Investigators:
Dr. Daniel Eichner; Sports Medicine Research and Testing Laboratory (SMRTL)
Dr. Anthony Butch; UCLA Olympic Analytical Laboratory
Lab Managers can apply for COE grants via regular PCC grant processes.
Principle Investigators:
Dr. Daniel Eichner; Sports Medicine Research and Testing Laboratory (SMRTL)
Dr. Anthony Butch; UCLA Olympic Analytical Laboratory
Lab Managers can apply for COE grants via regular PCC grant processes.
2019 Grants
In Progress
Principle Investigator:
Dr. Soledad Rubio Bravo, University of Cordoba.
2018 Grants
In Progress
Principle Investigator:
Dr. David Handelsman, ANZAC Research Institute, University of Sydney
In Progress
Principle Investigator:
Dr. Alexandre Marchand, AFLD
In Progress
Principle Investigator:
Dr. Michael Polet, University of Ghent
In Progress
Principle Investigator:
Dr. Mario Thevis; German Sport University Cologne
Associated Project:
2017 Grants
Identification of New Testosterone Biomarkers by an Untargeted Steroidomic Profiling in Blood Matrix
Principle Investigator:
Dr. Raul Nicoli; Swiss Anti-Doping Laboratory
Principle Investigator:
Dr. Zach Gagnon; John Hopkins University
Principle Investigator:
Dr. Jentsan Chi; Duke University
Comprehensive Steroid Detection in Urine Via Targeted Clean-Up and Fully Automated GCxGC-MS Analysis
Principle Investigator:
Dr. Nicholas Turner; The Open University
Principle Investigator:
Dr. Corinne Buisson; AFLD – Agence française de lutte contre le dopage
Principle Investigator:
Dr. Daniel Eichner; Sports Medicine Research and Testing Laboratory (SMRTL)
Principle Investigator:
Dr. Daniel Eichner; Sports Medicine Research and Testing Laboratory (SMRTL)
Principle Investigator:
Dr. Jentsan Chi; Duke University
Media:
https://cleancompetition.org/2018/04/19/just-funded-dr-chi/
Principle Investigator:
Dr. Christiane Ayotte; INRS Santé
Principle Investigator:
Dr. Paul Armishaw; National Measurement Institute
2016 Grants
Principle Investigator:
Dr. Nicolas Voelcker; Monash University
Principle Investigator:
Dr. James Harynuk; University of Alberta
Dr. Fred West; University of Alberta
Principle Investigator:
Dr. Emad Kiriakous; Queensland University
Principle Investigator:
Dr. Fred Schaufele; Xcell Assay
Principle Investigator:
Dr. Gaetano Cairo; University of Milan
Principle Investigator:
Dr. Christiane Ayotte; INRS Santé
Principle Investigator:
Dr. Judith Su; University of Arizona
Principle Investigator:
Dr. Nikolai Nordsborg; University of Copenhagen
Principle Investigator:
Dr. Mario Thevis; German Sport University Cologne
Principle Investigator:
Dr. Herb Tobias; Dell Pediatric Research Institute
2015 Grants
Principle Investigator:
Dr. Jack Henion; Q2 Solutions
Publications:
Analytical Chemistry: A Book-Type Dried Plasma Spot Card for Automated Flow-Through Elution Coupled with Online SPE-LC-MS/MS Bioanalysis of Opioids and Stimulants in blood
Drug Testing and Analysis: Quantitative determination of opioids in whole blood using fully automated dried blood spot desorption coupled to on-line SPE-LC-MS/MS.
Bioanalysis: Novel membrane devices and their potential utility in blood sample collection prior to analysis of dried plasma spots
Presentations:
Henion, J, Ryona, I. New Microsampling Hematocrit-Compatible Dried Plasma Card for Fully Automated On-Line DBSA-SPE-LC/MS/MS Bioanalysis of Opioids in Blood. Monday 6 June 2016 in San Antonio, TX on the first day of ASMS
Henion, J. Alternative Matrices: Dried Plasma Spots. April 11, 2017. Partnership for Clean Competition Conference. New York, NY.
Principle Investigators:
Dr. Peter Van Eenoo; University of Ghent Doping Control Laboratory
Dr. Michael Polet; University of Ghent
Publications:
Journal of Chromatography: Improved sensitivity by use of gas chromatography-positive chemical ionization trip quadrupole mass spectrometry for the analysis of drug related substances.
Rapid Communications in Mass Spectrometry: Gas chromatography/chemical ionization triple quadrupole mass spectrometry analysis of anabolic steroids: ionization and collision-induced dissociation behavior.
Journal of Mass Spectrometry: Efficient approach for the detection and identification of new androgenic metabolites by applying SRM GC-CI-MS/MS: a methandienone case study.
Presentations:
Improved sensitivity by using chemical ionization GC-MS/MS M. Polet, W. Van Gansbeke, F. Hooghe and P. Van Eenoo 33rd Cologne workshop on Dope Analysis 01/03/2015 – 06/03/2015
Chemical ionization GC-MS/MS analysis of anabolic androgenic steroids M. Polet, W. Van Gansbeke and P. Van Eenoo 34th Cologne workshop on Dope Analysis 21/02/2016 – 26/02/2016
Chemical ionization GC-MS/MS analysis of anabolic androgenic steroids M. Polet, W. Van Gansbeke and P. Van Eenoo Agilent Nordic Scientific Forum 2016 (Gothenburg) 10/03/2016 – 11/03/2016
Principle Investigator:
Dr. Herbert Tobias; Cornell University
Presentation:
Tobias, H.J.; Brenna, J.T. ” Cryogenic-Focusing Fast Gas Chromatography Isotope Ratio Mass Spectrometry,” 64nd ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio TX, June 1-June 5, 2016.
Publications:
Manuscript in Progress
Principle Investigator:
Dr. Eleftherios Diamandis; Mount Sinai Hospital, Toronto
Publications:
Clinical Chemistry: Prostate-Specific Antigen as a Marker of Hyperandrogenism in Women and Its Implications for Antidoping
Clinical Chemistry and Laboratory Medicine: Effect of age on serum prostate-specific antigen in women.
Clinical Chemistry and Laboratory Medicine: Serum complexed and free prostate-specific antigen (PSA) for the diagnosis of the polycystic ovarian syndrome (PCOS)
Sports Medicine: Serum complexed and free prostate specific antigen levels are lower in female elite athletes in comparison to control women. [submitted for publication].
Principle Investigator:
Dr. Paul Gregorevic; Baker IDI and Diabetes Institute
Principle Investigator:
Dr. Laura Garvican-Lewis; Australian Institute of Sport
Principle Investigator:
Dr. Nikolai Nordsborg; University of Copenhagen
Publications:
Drug Testing & Analysis: New insights for identification of doping with recombinant human erythropoietin micro-doses after high hydration
Scandanavian Journal of Science and Medicine in Sports: Acute hyperhydration reduces athlete biological passport OFF-hr score
Principle Investigator:
Dr. Paul Armishaw; National Measurement Institute
Principle Investigator:
Dr. Stephen Davies; National Measurement Institute
Principle Investigator:
Dr. Daniel Eichner; Sports Medicine Research and Testing Laboratory (SMRTL)
Principle Investigator:
Dr. Lore Geldof; University of Ghent
Presentations:
Geldof L, Ryckx A, Verelst C, Deventer K and Van Eenoo P. Preventive anti-doping research of small molecule erythropoiesis stimulating agents: HIF stabilizers. 35th Manfred Donike Workshop on Dope Analysis. 2017. Cologne, Germany.
Publications:
Biomedical Chromatography: In vitro and in vivo metabolism studies of dimethazine
Principle Investigator:
Dr. Chris Harrison; San Diego State University
Presentations:
Harrison, C. Next Generation Technology for Anti-Doping: Electrophoretic Separations. 2017. 2017 Partnership for Clean Competition Conference. New York, NY.
Principle Investigator:
Dr. Christian Reichel; Seibersdorf Labor GmbH Doping Control Laboratory
Principle Investigator:
Dr. Richard Yost; University of Florida
Presentation:
Allison J. Levy1, Christopher D. Chouinard,1 Robin H. J. Kemperman,1 Nicholas R. Oranzi,1 Richard A. Yost1 . Improved Separation and Detection of Exogenous and Endogenous Isomeric Steroids Using Ion Mobility-Mass Spectrometry. 2017. American Society for Mass Spectrometry Annual Conference. Indianapolis, IN.
Principle Investigator:
Dr. Daniel Eichner; Sports Medicine Research and Testing Laboratory (SMRTL)
Publications:
Drug Testing and Analysis: Intranasal delivery of Natesto testosterone gel and its effects on doping markers
Principle Investigator:
Dr. Nicolas Voelcker; Monash University, Australia
2014 Grants
Principle Investigator:
Dr. Jack Henion; Q2 Solutions
Publications:
Drug Testing and Analysis: Quantitative determination of opioids in whole blood using fully automated dried blood spot desorption coupled to on-line SPE-LC-MS/MS.
Complete.
Principle Investigator:
Dr. Kara Lynch; University of California San Francisco
Publications:
Analytical Toxicology: Optimization and Validation of High-Resolution Mass Spectrometry Data Analysis Parameters
Clinical Chemistry: Comparison of Information-Dependent Acquisition on a Tandem Quadrupole TOF vs a Triple Quadrupole Linear Ion Trap Mass Spectrometer for Broad-Spectrum Drug Screening
Presentations:
Mass Spectrometry: Applications to the Clinical Lab Conference, San Diego, CA. “Broad Spectrum Screening Using Liquid Chromatography Quadrupole TOF MS: How Valuable is Retention Time for Identifying Compounds.” 03/2015
Mass Spectrometry: Applications to the Clinical Lab Conference, San Diego, CA. “Comparing TOF& QTOF for Comprehensive Drug Screening: Do You Really Need Fragmentation Information.” 03/2015
International Association of Therapeutic Drug Monitoring and Clinical Toxicology 14th International Congress, Rotterdam, Netherlands. “Optimization of data analysis parameters for clinical toxicology testing using high resolution mass spectrometry” 10/2015
Mass Spectrometry: Applications to the Clinical Laboratory Conference, Palm Springs, CA. “High Resolution Mass Spectrometry for Suspect Screening of Novel Psychoactive Substances: Is it a Viable Solution for Laboratories.” 02/2016
Mass Spectrometry: Applications to the Clinical Laboratory Conference, Palm Springs, CA. “New Library Search Algorithm Improves Identification of Drugs by LC-QqTOF” 02/2016
Yale University, Department of Laboratory Medicine, Research Conference Series. “Analytical Advances in Clinical Toxicology using High Resolution Mass Spectrometry.” 04/2016
Analytical World Conference/Society of Toxicological and Forensic Chemistry, Munich, Germany. “Q-TRAP or Q-TOF for comprehensive drug screening?” 05/2016
Principle Investigator:
Dr. Benjamin Levine; UT Southwestern Medical Center
Presentations:
Lawley JS, Gatterer H. Howden EJ, Sarma S, Hearon C, Hieda M, Hendrix M, Piper T, Thevis M, Levine BD. Xenon: The Good, the Bad and the Doping”. Poster presented, Int’l Hypoxia Symposium, 2/9/17.
Principle Investigators:
Sports Medicine Research and Testing Laboratory (SMRTL) and UCLA Olympic Analytical Laboratory WADA Accredited Labs
Principle Investigator:
Dr. Mike Ashenden; Science and Industry Against Blood doping (SIAB)
Publications:
Medicine and Science in Sports: Acute hyperhydration reduces athlete biological passport OFF-hr score
Principle Investigator:
Dr. Richard Holt; University of Southampton
Publications:
Drug Testing and Analysis: Novel markers to detect recombinant human insulin-like growth factor-I (rhIGF-I)/rhIGF binding protein-3 (rhIGFBP-3) misuse in athletes
Drug Testing and Analysis: Biochemical markers of recombinant human insulin-like growth factor-I (rhIGF-I)/rhIGF binding protein-3 (rhIGFBP-3) misuse in athletes.
BMC Medical Research Methodology: Statistical methodology for age-adjustment of the GH-2000 score detecting growth hormone misuse
Indian Journal of Endocrinology and Metabolism: Detecting growth hormone misuse in athletes
Principle Investigator:
Dr. David Chen; University of British Columbia
Principle Investigator:
Dr. Daniel Eichner; Sports Medicine Research and Testing Laboratory (SMRTL)
Principle Investigator:
Dr. Daniel Eichner; Sports Medicine Research and Testing Laboratory (SMRTL)
Principle Investigator:
Dr. Peter Van Eenoo; Doping Control Laboratory, University of Ghent
Publications:
International Journal of Molecular Sciences: In vitro metabolic studies of REV-ERB agonists SR9009 and SR9011
Presentations:
Geldof L, Deventer K, Tudela E and Van Eenoo P. In vitro metabolism studies of REV-ERBα agonists SR9009 and SR9011. 34th Manfred Donike Workshop on Dope Analysis. 2016. Cologne, Germany.
Principle Investigator:
Dr. David Cowan; King’s College London Drug Control Centre
Presentations:
Analytical and Environmental Sciences Division Symposium, King’s College London:
- 2015- Poster Presentation: Towards quantifying PIIINP in human serum by LC-MS: identifying suitable surrogate peptides
- 2016- Poster Presentation: Towards quantifying PIIINP in human serum by LC-MS: separating PIIINP from human serum albumin
Principle Investigator:
Dr. Mario Thevis; German Sport University Cologne
Publications:
Analytical & Bioanalytical Chemistry: Qualitative identification of growth hormone-releasing hormones in human plasma by means of immunoaffinity purification and LC-HRMS/MS
Presentations:
Qualitative identification of growth hormone-releasing hormones in human plasma by means of immunoaffinity purification and LC-HRMS/MS. Thevis, M. 2016. 34th Cologne workshop on Dope Analysis. Cologne, Germany.
Principle Investigator:
Dr. Pauline Rudd; NIBRT
2013 Grants
Detecting bio-molecules by nanotechnology & Raman spectroscopy: Rapid Screening kit for EPO in urine
Principle Investigator:
Dr. Emad Kiriakous; Queensland University
Publications:
Journal of Nanobiotechnology: Reproducible and label-free biosensor for the selective extraction and rapid detection of proteins in biological fluids
Queensland University of Technology: A Novel identification method for ultra trace detection of biomolecules using functionalized-surface enhanced Raman Spectroscopy (SERS)
Presentations:
Hughes, Juanita, Izake, Emad L., Lott, William B., & Ayoko, Godwin A. (2014) Label-free SERS for natural product provenance. In 24th Anniversary World Congress on Biosensors, 28-30 May 2014, Melbourne Convention and Exhibition Centre, Melbourne, VIC.
Hughes, Juanita, Lott, William B., Ayoko, Godwin A., Sillence, Martin, & Izake, Emad L. (2013) Ultra-trace detection of diagnostically important biomarkers using functionalised-Surface Enhanced Raman Spectroscopy (SERS). In Eighth ISABS Conference on Forensic, Anthropologic and Medical Genetics and Mayo Clinic Lectures in Translational Medicine, 24-28 June 2013, Split, Croatia.
Principle Investigator:
Dr. Ruprecht Keller; Cologne Central Hospital Lab.
Publications:
Sports Medicine: The Urine Marker Test: An Alternative Approach to Supervised Urine Collection for Doping Control
Principle Investigator:
Dr. Rodrigo Aguilera
Presentation:
Alexandra Goncalves, Beatriz Salema, João Ruivo, Sandra Ramos, Susana Luz, Thomas Chapman and Rodrigo Aguilera. “Development and validation of a methodology for the detection of synthetic forms of Endogenous Anabolic Androgenic Steroids in urine samples by GC-C-IRMS.”XVI Latino-Americano Conference on Chromatography. Lisbon, 5 to 9 January 2016
Principle Investigator:
Dr. Anthony Butch; UCLA Olympic Analytical Laboratory
Presentations:
Tu, M., Chia, D., Wei, F., Wong, D., and Butch, A. Amperometric Immunosensor for Detecting Growth Hormone Use by Athletes. 15th Annual UC Systemwide Bioengineering Symposium. June 2014, California, USA.
Principle Investigator:
Dr. David Cowan; King’s College London Drug Control Centre
Presentations:
Analytical and Environmental Sciences Division Symposium, King’s College London:
- 2015- Poster Presentation: Towards quantifying PIIINP in human serum by LC-MS: identifying suitable surrogate peptides
- 2016- Poster Presentation: Towards quantifying PIIINP in human serum by LC-MS: separating PIIINP from human serum albumin
Principle Investigator:
Dr. Tom Brenna; Cornell University
Presentation:
Tobias, H.J.; Ruesch, J.M.; Brenna, J.T. “High Volume Steroid Stable Isotopic Standards for Anti-Doping Applications,” 63nd ASMS Conference on Mass Spectrometry and Allied Topics, St. Louis MO, May 31-June 4, 2015.
Principle Investigator:
Dr. David Cowan; King’s College London Drug Control Centre
Principle Investigator:
Dr. Detlaf Thieme; IDAS Dresden
Principle Investigator:
Dr. Christoph Borchers; University of Victoria
Publications:
Molecular and Cellular Proteomics: Multiple Reaction Monitoring Enables Precise Quantification of 97 Proteins in Dried Blood Spots
Presentations:
Andrew G. Chambers, Andrew J. Percy, Juncong Yang and Christoph H. Borchers, “Highly‐Multiplexed
Protein Quantification from Dried Blood Spots.” 13th Human Proteome Organization World, Madrid,
Spain, October 2014.
Andrew G. Chambers, Andrew J. Percy, Juncong Yang and Christoph H. Borchers, “Quantitative Dried
Blood Spot Proteomics by LC‐MRM‐MS.” 63rd American Society for Mass Spectrometry, St. Louis,
Missouri, USA, May 2015.
Christoph H. Borchers, “MRM and iMALDI for Clinical Research and Diagnostic.” Proteomic Forum Berlin,
Berlin, Germany, March 2015.
Christoph H. Borchers, “Multiplexed Protein Quantitation in Biofluids and Dried Blood Spots by 1D
and/or 2D LC‐MRM/MS for Biomarker Assessment” Agilent Webinar, March 2015.
2012 Grants
Principle Investigator:
Dr. James Watkins; Norwich Ventures
Principle Investigator:
Dr. Frank Suhr; German Sport University Cologne
Principle Investigator:
Dr. Daniel Eichner; Sports Medicine Research and Testing Laboratory (SMRTL)
Presentations:
Cox, HD, Eichner, D. Targeted quantification of blood cell marker proteins in dried blood spots for the detection of blood doping practices in sport. June 2015. 63rd Meeting of the American Society for Mass Spectrometry. St. Louis, MO.
Cox, HD, Eichner, D. Preliminary evaluation of a novel dried blood spot-based methodology for the detection of blood doping practices in sport. September 2014. USADA Science Symposium. Phoenix, AZ.
Cox, HD, Hughes, CM, Eichner, D. Method to detect blood doping practices in sport through the measurement of reticulocytes in dried blood spots by LC-MS/MS. June 2014. 62nd Meeting of the American Society for Mass Spectrometry. Baltimare, MD.
Principle Investigator:
Dr. Mike Ashenden; Science and Industry Against Blood doping (SIAB) Australia
Principle Investigator:
Dr. Jenny Schulze; Karolinska Institutet
Publications:
Frontiers in Endocrinology: The impact of genetics and hormonal contraceptives on the steroid profile in female athletes
Drug Testing and Analysis: Urinary steroid profile in females – the impact of menstrual cycle and emergency contraceptives
Presentation:
Schulze, J. The impact of CYP17 polymorphims and hormonal contraceptives on the steroid profile in female athletes . 32nd Manfred Donike Cologne Workshop on Dope Analysis. 2014. Cologne, DE.
Principle Investigator:
Dr. Philip Smith; University of North Carolina at Chapel Hill
Presentation:
Fallon, K, and Smith, PC. Does Interindividual UGT2B17 Expression and Testosterone Glucuronidation Support the Use of the Testosterone/Epitestosterone (T/E) Ratio? 2015. 20th North American ISSX Conference. Orland, FL.
2011 Grants
Principle Investigator:
Dr. Barbara Daniel; King’s College London
Presentation:
Daniel, B. Can Genomic Analysis Be the Answer to Autologous Blood Transfusion Detection?PCC Conference ‘The Doping Decision: Deterring Doping in Sport’. December 2011, New York.
Principle Investigator:
Dr. Richard Snyder; University of Florida
Publications:
Analytical and Bioanalytical Chemistry: PCR-based Detection of Gene Transfer Vectors: Application to Gene Doping Surveillance
Presentations:
Ni, Y., Le Guiner, C., Penaud-Budloo, M., Moullier, P., and Snyder, R.O. Molecular Detection of rAAV Vector Sequences in Blood. 17th Molecular Virology Workshop, April 23 – 24, 2010. Daytona Beach, FL.
Ni, Y., Le Guiner, C., Penaud-Budloo, M., Moullier, P., and Snyder, R.O. Molecular Detection of rAAV Genomes in Blood of Non-Human Primates: Development of a Reliable Blood Test for the Detection of Gene Doping. European Society of Gene and Cell Therapy Annual Meeting. October 22-25, 2010. Milan, Italy
Ni, Y., Le Guiner, C., Penaud-Budloo, M., Moullier, P., and Snyder, R.O. Longevity of rAAV Vector and Plasmid DNA in Blood after Intramuscular Injection in Non-Human Primates. 18th Molecular Virology Workshop, May 6-7, 2011. Daytona Beach, FL.
Perez, I.C., Le Guiner, C., Moser, D., Simon, P., Moullier, P., and Snyder, R.O. Comparing PCR Conditions That Detect rAAV Harboring the Human Erythropoietin cDNA: Applications for Gene Doping. Florida Genetics Symposium. November 28-29, 2012. Gainesville, FL.
Perez, I.C., Ni, W., Le Guiner, C., Moser, D., Simon, P., Moullier, P., and Snyder, R.O. Comparing PCR Conditions That Detect a rAAV Vector Harboring the Human Erythropoietin cDNA: Applications for Gene Doping. 20th Molecular Virology Workshop, April 26 – 27, 2013. Daytona Beach, FL.
Perez, I.C., Ni, W., Le Guiner, C., Moser, D., Simon, P., Moullier, P., and Snyder, R.O. Comparing PCR Conditions That Detect rAAV Harboring the Human Erythropoietin cDNA: Applications for Gene Doping. UF NSF Research Day. October 29, 2013. Gainesville, FL.
Perez, I.C., Ni, W., Le Guiner, C., Moser, D., Simon, P., Moullier, P., and Snyder, R.O. Comparing PCR Conditions That Detect rAAV Harboring the Human Erythropoietin cDNA: Applications for Gene Doping. Florida Genetics Symposium. October 9-10, 2013. Gainesville, FL.
Principle Investigator:
Dr. Andy Hoofnagle; University of Washington
Publications:
Clinical Chemistry: Interlaboratory agreement of insulin-like growth factor 1 concentrations measured by mass spectrometry
Presentations:
Hoofnagle, A. “Prioritizing Our Validation Efforts.” Proteomics in the Clinic (Hosted by the FDA). Silver Spring, MD. (June 2014)
Hoofnagle, A. “If It’s Broke, Why Not Fix It? How Mass Spectrometry Can Make the Most of Our Precious Samples.” Advancing translational research Using mass spectrometry (Hosted by the Duke Proteomics Core Facility with Support From the Duke Translational Research Institute). Durham, NC. (May 2014)
Hoofnagle, A. “What Contributes to Inter-laboratory Variability of Targeted Protein LC-MS/MS Assays: A Case Study Using IGF-1.” Mass Spectrometry: Applications to the Clinical Laboratory Annual Meeting, San Diego, CA. (March 2014)
Principle Investigator:
Dr. Marijke Grau; German Sport University Cologne
Publications:
Clinical Hemorheology and Microcirculation: Decrease in red blood cell deformability is associated with a reduction in RBC-NOS activation during storage
Principle Investigator:
Dr. Donald Siegel; University of Pennsylvania
Publications:
Immunologic Research: Translational applications of antibody phage display
Emerging Technologies in Transfusion Medicine: Diagnostic and Therapeutic Applications of Phage Display Technology
Principle Investigator:
Dr. Thomas Piper; Deutsche Sporthochschule Koln
Publications:
Drug Testing and Analysis: Investigations on hydrogen isotope ratios of endogenous urinary steroids: reference population-based thresholds and proof-of-concept
Analytical and Bioanalytical Chemistry: Effect of changes in the deuterium content of drinking water on the hydrogen isotope ratio of urinary steroids in the context of sports drug testing.
Analytical and Bioanalytical Chemistry: Combination of carbon isotope ratio with hydrogen isotope ratio determinations in sports drug testing
Presentations:
Manfred Donike Workshop – 30th Workshop on Dope Analysis, 26.02 to 02.03.2012, Cologne, Germany
Joint European Stable Isotope Users Group Meeting – JESIUM 2012, 2–7 September 2012, Leipzig, Germany
Manfred Donike Workshop – 31st Workshop on Dope Analysis, 24.02 to 01.03.2013, Cologne, Germany
Jahrestagung der Deutschen Gesellschaft für Massenspektrometrie, 10.03 to 13.03.2013, Berlin, Germany
2010 Grants
Principle Investigator:
Dr. Jason Dragoo; Leland Stanford Junior University
Publications:
The American Journal of Sports Medicine: The Systemic Effects of Platelet-Rich Plasma Injection
Presentations:
Wasterlain AS, Braun HJ, Kim HJ, Dragoo JL. “Systemic Performance-Enhancing Effects of Platelet-Rich Plasma (PRP) Injection.” European Society of Sports Traumatology, Knee Surgery and Arthroscopy (ESSKA) Congress, Geneva, Switzerland. May 4, 2012.
Wasterlain AS, Braun H, Harris A, Kim HJ, Dragoo JL. “Systemic Performance-Enhancing Effects of Platelet-Rich Plasma (PRP) Injection.” American Academy of Orthopaedic Surgeons (AAOS) Congress, Chicago, IL. Mar 19-23, 2013.
Wasterlain AS, Braun HJ, Kim HJ, Dragoo JL. “Systemic Performance-Enhancing Effects of Platelet-Rich Plasma (PRP) Injection.” Arthroscopy Association of North America (AANA) Annual Meeting, Orlando, FL. May 19, 2012.
Wasterlain AS, Braun HJ, Kim HJ, Dragoo JL. “Effect of Platelet-Rich Plasma Injection on Systemic Concentrations of Performance-Enhancing Growth Factors.” Orthopaedic Research Society (ORS) Congress, San Francisco, CA. Feb 6, 2012.
Principle Investigator:
Dr. David Bruns; University of Virginia
Publications:
Clinica Chimica Acta: Quantification of growth hormone mRNA in blood.
Drug Testing and Analysis: Circulating miRNA as a biomarker of human growth hormone administration to patients.
Presentations:
BN Kelly, DM Haverstick, ML Vance, MD Thorner and DE Bruns. Circulating RNAs as markers of growth hormone doping. Growth Hormone and IGF-1 Research Society Meeting, October 2012, MUNICH
Kelly BN, Haverstick DM, Bruns DE. Circulating RNAs as Markers of Growth Hormone Doping. 2012 Meeting. Growth Hormone Research Society. Berlin.
Kelly BN, Haverstick DM, Bruns DE. Circulating RNA as a marker for growth hormone doping. 2012 Academy of Clinical Laboratory Physicians and Scientists (ACLPS) Annual Meeting, Milwaukee.
Kelly BN, Haverstick DM, Bruns DE. Detection of growth hormone mRNA in circulation. 2011 Academy of Clinical Laboratory Physicians and Scientists (ACLPS) Annual Meeting, St. Louis. (Young Investigator Award, Kelly).
Kelly BN, Haverstick DM, Bruns DE. RNA-Biomarker approaches for detection of recombinant human growth hormone abuse. US Antidoping Agency Meeting, London, UK. September, 2011.
Kelly BN, Haverstick DM, Bruns DE. Pathology Research Progress Report meeting; October, 2011, Charlottesville, VA
Principle Investigator:
Dr. Pauline Rudd; National Institute for Bioprocessing Research and Training
Principle Investigator:
Dr. Andrew Kicman; King’s College London
Principle Investigator:
Dr. Richard Holt; University of Southampton
Publications:
Drug Testing and Analysis: Novel markers to detect recombinant human insulin-like growth factor-I (rhIGF-I)/rhIGF binding protein-3 (rhIGFBP-3) misuse in athletes
Drug Testing and Analysis: Biochemical markers of recombinant human insulin-like growth factor-I (rhIGF-I)/rhIGF binding protein-3 (rhIGFBP-3) misuse in athletes.
BMC Medical Research Methodology: Statistical methodology for age-adjustment of the GH-2000 score detecting growth hormone misuse
Indian Journal of Endocrinology and Metabolism: Detecting growth hormone misuse in athletes
Principle Investigator:
Dr. Monica Mazzarino; Labortio anti doping FMSI
Principle Investigator:
Dr. Daniel Eichner; Sports Medicine Research and Testing Laboratory (SMRTL)
Principle Investigator:
Dr. Nicolas Leuenberger; Swiss Laboratory for Anti-Doping Analyses
Publications:
Analytical and Bioanalytical Chemistry: Circulating miRNAs: a new generation of anti-doping biomarkers
PLoS One: Circulating microRNAs as Biomarkers for Detection of Autologous Blood Transfusion
Advances in Experimental Medicine and Biology: Circulating microRNAs : The future of Biomarkers in Anti-doping Field
Transfusion Medicine Reviews : Autologous Blood Transfusion in Sports : Emerging Biomarkers
Presentations:
Circulating microRNAs to detect autologous blood transfusion. Presented by: N Leuenberger, YO Schumacher, T Pottgieser, M Saugy and S Pradervand. The Manfred Donike Workshop on Doping Analysis, February 2012, COLOGNE
Principle Investigator:
Dr. Svetlana Appolonova; Moscow Anti-Doping Laboratory
Presentations:
Appolonova, S. A., Mesonzhnik N.V. and Rodchenkov, G. M. (2012), Multivariate analysis in combination with electrospray ionization tandem mass spectrometry as a model for prediction of 3-ketosteroids’ and corticosteroids’ structures // Eighth Winter Symposium on Chemometrics “Modern Methods of Data Analysis”. Russia, Drakino, February 27 – March 2, 2012, P. 51-52
Mesonzhnik N.V., Appolonova, S. A., and Rodchenkov, G. M. (2012), Detecting unexpected drugs of abuse using UPLC-HRMS in combination with multivariate analysis // Eighth Winter Symposium on Chemometrics “Modern Methods of Data Analysis”. Russia, Drakino, February 27 – March 2, 2012, P. 52-53
Svetlana Appolonova, Natalia Mesonzhnik, Daria Brazhnikova and Grigory Rodchenkov. PLS-DA and OPLS-DA as a model for prediction of the steroids structures // 29th (MONTREUX) SYMPOSIUM on Liquid Chromatorgaphy/Mass Spectrometry, 7-9 November, 2012, p. 10
Svetlana Appolonova, Natalia Mesonzhnik, Daria Brazhnikova and Grigory Rodchenkov. Validation of multivariate analysis for classification of anabolic steroids and corticosteroids by MS/MS spectra // 29th (MONTREUX) SYMPOSIUM on Liquid Chromatorgaphy/Mass Spectrometry, 7-9 November, 2012, p. 11
Principle Investigator:
Dr. Andrew Phillips; Yale University
2009 Grants
Principle Investigator:
Dr. Fred Schaufele; UC San Francisco
Publications:
Principle Investigator:
Dr. Peter Van Eenoo; University of Ghent Doping Control Laboratory
Publications:
Biomedical Chromatography: In-vitro and in-vivo metabolism studies of dimethazine
Biomedical Chromatography: Metabolism of methylstenbolone studied with human liver microsomes and the uPA⁺/⁺-SCID chimeric mouse model
Presentations:
Presentation: Geldof L, Lootens L, Deventer K, Polet M, Eichner D, Botrè F, Meuleman P, Leroux-Roels G, Van Eenoo P. In vitro and in vivo metabolism studies of a nutritional supplement containing methylstenbolone. 31st Cologne Workshop on Dope Analysis. 2013. Cologne, Germany.
Lootens L, Geldof L, Meuleman P, Leroux-Roels G, Deventer K, Van Eenoo P. Steroid metabolism studied via a chimeric mouse model in the framework of sports doping. 7th International Symposium Hormone and Veterinary Drug Residue Analysis. June 2014. Ghent, Belgium.
Geldof L, Lootens L, Van Lysebeth J, Meuleman P, Leroux-Roels G, Deventer K, Van Eenoo P. Metabolic study of a steroid product containing dimethazine using human liver microsomes and a chimeric mouse model. 32nd Cologne Workshop on Dope Analysis. 2014. Cologne, Germany.
Principle Investigator:
Dr. Michael Collins; National Measurement Institute, Australia
Publications:
Drug Testing and Analysis: Stable carbon isotope ratio profiling of illicit testosterone preparations – domestic and international seizures