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Dried Plasma Spot (DPS) Card Development

Dried Plasma Spot (DPS) Card Development2018-06-27T17:43:40+00:00

Project Description

 

Project Start: 2014

Team:

Dr. Jack Henion (former primary investigator)
Dr. Imelda Ryona

Summary:
Dried Plasma Spot testing offers the potential for a less expensive, less invasive, and easier to transport alternative to typical blood or urine samples. Through research begun in 2014 by Dr. Henion and continued by Dr. Ryona, the PCC is pursuing the development of a novel card device for efficient, point-of-care collection, transport, and analysis of plasma and whole blood. The card is designed to provide micro plasma samples without the need for centrifugation or other laboratory techniques for producing plasma, and allow for inexpensive shipping and efficient analysis.

Potential DPS Benefits:

  • Less invasive out-of-competition sampling
  • Eliminates the need for a phlebotomist, saving costs
  • Enhanced sample stability, especially for the hematological module of the ABP

Next Steps: 

Tooling Development is in progress, while production of 2,500 cards is underway for further testing in 2018.

Media: 

Publications to Date:

RYONA, I., AND HENION, J. A BOOK-TYPE DRIED PLASMA SPOT CARD FOR AUTOMATED FLOW-THROUGH ELUTION COUPLED WITH ONLINE SPE-LC-MS/MS BIOANALYSIS OF OPIOIDS AND STIMULANTS IN BLOOD.  ANALYTICAL CHEMISTRY. 88 (22), 11229–11237, DOI: 10.1021/ACS.ANALCHEM.6B03691, 2016.
VERPLAETSE, R., AND HENION, J. HEMATOCRIT-INDEPENDENT QUANTITATION OF STIMULANTS IN DRIED BLOOD SPOTS: PIPET VERSUS MICROFLUIDIC-BASED VOLUMETRIC SAMPLING COUPLED WITH AUTOMATED FLOW-THROUGH DESORPTION AND ONLINE SOLID PHASE EXTRACTION-LC-MS/MS BIOANALYSIS. ANAL CHEM, JUL 5;88(13), 6789-96. DOI: 10.1021/ACS.ANALCHEM.6B01190, 2016.
VERPLAETSE, R., AND HENION, J. QUANTITATIVE DETERMINATION OF OPIOIDS IN WHOLE BLOOD USING FULLY AUTOMATED DRIED BLOOD SPOT DESORPTION COUPLED TO ON-LINE SPE-LC-MS/MS. DRUG TESTING AND ANALYSIS. 8, 30–38. DOI: 10.1002/DTA.1927, 2016.
STURM, R., HENION, J., ABBOT, R., WANG, P. NOVEL MEMBRANE DEVICES AND THEIR POTENTIAL UTILITY IN BLOOD SAMPLE COLLECTION PRIOR TO ANALYSIS OF DRIED PLASMA SPOTS. BIOANALYSIS. 7 (16):1987-2002. DOI 10.4155/BIO.15.98, 2015.

Presentations to Date: 

HENION, J. ALTERNATIVE MATRICES: DRIED PLASMA SPOTS. 2017 PCC CONFERENCE. 2017. NY, USA.
HENION, J. POTENTIAL ANALYTICAL STRATEGIES FOR THE DETERMINATION OF CANNABINOIDS IN BIOLOGICAL SAMPLES. MASS SPECTROMETRY: APPLICATIONS TO THE CLINICAL LAB. 2017. CHICAGO, USA.
HENION, J. POTENTIAL ANALYTICAL STRATEGIES FOR THE DETERMINATION OF CANNABINOIDS IN BIOLOGICAL SAMPLES. PITTCON CONFERENCE AND EXPO. 2017. CHICAGO, USA.
HENION, J., RYONA, I. NEW MICROSAMPLING HEMATOCRIT-COMPATIBLE DRIED PLASMA CARD FOR FULLY AUTOMATED ON-LINE DBSA-SPE-LC/MS/MS BIOANALYSIS OF OPIOIDS IN BLOOD. 2016 AMERICAN SOCIETY FOR MASS SPECTROMETRY CONFERENCE. 2016. SAN ANTONIO, USA.

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