Project Start: 2014
Dr. Jack Henion (former primary investigator)
Dr. Imelda Ryona
Dried Plasma Spot testing offers the potential for a less expensive, less invasive, and easier to transport alternative to typical blood or urine samples. Through research begun in 2014 by Dr. Henion and continued by Dr. Ryona, the PCC is pursuing the development of a novel card device for efficient, point-of-care collection, transport, and analysis of plasma and whole blood. The card is designed to provide micro plasma samples without the need for centrifugation or other laboratory techniques for producing plasma, and allow for inexpensive shipping and efficient analysis.
Potential DPS Benefits:
- Less invasive out-of-competition sampling
- Eliminates the need for a phlebotomist, saving costs
- Enhanced sample stability, especially for the hematological module of the ABP
Tooling Development is in progress, while production of 2,500 cards is underway for further testing in 2018.
- Dr. Jack Henion Presents Novel Dried Plasma Spot Anti-Doping Technology (video)
- Award: Outstanding Contribution to Anti-Doping Science (2017): Dr. Jack Henion and Dr. Imelda Ryona
- Dr. Imelda Ryona: From Food Science to Anti-Doping
- PCC Spring 2016 Newsletter with Dried Blood Spot Feature
- What’s Next Wednesday: Dried Blood Spot Sampling
Publications to Date:
RYONA, I., AND HENION, J. A BOOK-TYPE DRIED PLASMA SPOT CARD FOR AUTOMATED FLOW-THROUGH ELUTION COUPLED WITH ONLINE SPE-LC-MS/MS BIOANALYSIS OF OPIOIDS AND STIMULANTS IN BLOOD. ANALYTICAL CHEMISTRY. 88 (22), 11229–11237, DOI: 10.1021/ACS.ANALCHEM.6B03691, 2016.
VERPLAETSE, R., AND HENION, J. HEMATOCRIT-INDEPENDENT QUANTITATION OF STIMULANTS IN DRIED BLOOD SPOTS: PIPET VERSUS MICROFLUIDIC-BASED VOLUMETRIC SAMPLING COUPLED WITH AUTOMATED FLOW-THROUGH DESORPTION AND ONLINE SOLID PHASE EXTRACTION-LC-MS/MS BIOANALYSIS. ANAL CHEM, JUL 5;88(13), 6789-96. DOI: 10.1021/ACS.ANALCHEM.6B01190, 2016.
VERPLAETSE, R., AND HENION, J. QUANTITATIVE DETERMINATION OF OPIOIDS IN WHOLE BLOOD USING FULLY AUTOMATED DRIED BLOOD SPOT DESORPTION COUPLED TO ON-LINE SPE-LC-MS/MS. DRUG TESTING AND ANALYSIS. 8, 30–38. DOI: 10.1002/DTA.1927, 2016.
STURM, R., HENION, J., ABBOT, R., WANG, P. NOVEL MEMBRANE DEVICES AND THEIR POTENTIAL UTILITY IN BLOOD SAMPLE COLLECTION PRIOR TO ANALYSIS OF DRIED PLASMA SPOTS. BIOANALYSIS. 7 (16):1987-2002. DOI 10.4155/BIO.15.98, 2015.
Presentations to Date: