The Partnership for Clean Competition aims to promote a holistic understanding of anti-doping. To move toward that goal, we’ve put together a selection of articles published in November 2020 that are relevant to clean sport. These articles may or may not stem from PCC-funded research. Posting them here should not be read as an endorsement of findings, but rather, an attempt to assemble the latest research in one place to make it easy to read and review.
Alaedini S, Amirahmadi M, Kobarfard F, Rastegar H, Nasirahmadi S, Shoeibi S. Survey of protein-based sport supplements for illegally added anabolic steroids methyltestosterone and 4-androstenedione by UPLC-MS/MS. Steroids. 2020 Nov 5;1[65:10]8758. doi: 10.1016/j.steroids.2020.108758. Epub ahead of print. PMID: 33161054. https://pubmed.ncbi.nlm.nih.gov/33161054/
Anjum GS, Mumtaz N, Saqulain G. Attitude of athletes towards doping: A dilemma in Pakistan. Pak J Med Sci. 2020 Nov-Dec;36(7):1579-1584. doi: 10.12669/pjms.36.7.1922. PMID: 33235578; PMCID: PMC7674904. https://pubmed.ncbi.nlm.nih.gov/33235578/
Coll S, Monfort N, Alechaga É, Matabosch X, Pozo OJ, Pérez-Mañá C, Ventura R. Elimination profiles of prednisone and prednisolone after different administration routes: Evaluation of the reporting level and washout periods to ensure safe therapeutic administrations. Drug Test Anal. 2020 Nov 8. doi: 10.1002/dta.2966. Epub ahead of print. PMID: 33161623. https://pubmed.ncbi.nlm.nih.gov/33161623/
de la Torre X, Iannone M, Botrè F. Improving the detection of anabolic steroid esters in human serum by LC-MS. J Pharm Biomed Anal. 2020 Nov [30:11]3807. doi: 10.1016/j.jpba.2020.113807. Epub ahead of print. PMID: 33281003. https://pubmed.ncbi.nlm.nih.gov/33281003/
Guha N, Nevitt SP, Francis M, Böhning W, Böhning D, Sönksen PH, Holt RIG. The effects of recombinant human insulin-like growth factor-1/insulin-like growth factor binding protein-3 administration on lipid and carbohydrate metabolism in recreational athletes. Clin Endocrinol (Oxf). 2020 Nov 29. doi: 10.1111/cen.14370. Epub ahead of print. PMID: 33249593. https://pubmed.ncbi.nlm.nih.gov/33249593/
Jessen S, Becker V, Rzeppa S, Backer V, Bengtsen K, Hullstein I, Dehnes Y, Hostrup M. Pharmacokinetics of salmeterol and its main metabolite α-hydroxysalmeterol after acute and chronic dry powder inhalation in exercising endurance-trained men: Implications for doping control. Drug Test Anal. 2020 Nov 17. doi: 10.1002/dta.2978. Epub ahead of print. PMID: 33210444. https://pubmed.ncbi.nlm.nih.gov/33210444/
Johnson E, van Heemst J, Benavides J, Gray B. Metabolism and excretion of the benzodiazepine analogue etizolam in the horse. Drug Test Anal. 2020 Nov 9. doi: 10.1002/dta.2967. Epub ahead of print. PMID: 33169539. https://pubmed.ncbi.nlm.nih.gov/33169539/
Knoop A, Planitz P, Wüst B, Thevis M. Analysis of cobalt for human sports drug testing purposes using ICP- and LC-ICP-MS. Drug Test Anal. 2020 Nov 3. doi: 10.1002/dta.2962. Epub ahead of print. PMID: 33142033. https://pubmed.ncbi.nlm.nih.gov/33142033/
Lalonde K, Barber A, Ayotte C. Two-dimensional HPLC purification of underivatized urinary testosterone and metabolites for compound specific stable carbon isotope analysis. Drug Test Anal. 2020 Nov 5. doi: 10.1002/dta.2964. Epub ahead of print. PMID: 33151038. https://pubmed.ncbi.nlm.nih.gov/33151038/
Liu W, Bretz F, Böhning D, Holt R, Böhning W, Guha N, Sönksen P, Cowan D. Comparison of normal distribution-based and nonparametric decision limits on the GH-2000 score for detecting growth hormone misuse (doping) in sport. Biom J. 2020 Nov 9. doi: 10.1002/bimj.202000019. Epub ahead of print. PMID: 33164238. https://pubmed.ncbi.nlm.nih.gov/33164238/
Luginbühl M, Gaugler S. Dried blood spots for anti-doping: Why just going volumetric may not be sufficient. Drug Test Anal. 2020 Nov 17. doi: 10.1002/dta.2977. Epub ahead of print. PMID: 33201591. https://pubmed.ncbi.nlm.nih.gov/33201591/
Nuntawong P, Ochi A, Chaingam J, Tanaka H, Sakamoto S, Morimoto S. The colloidal gold nanoparticle-based lateral flow immunoassay for fast and simple detection of plant-derived doping agent, higenamine. Drug Test Anal. 2020 Nov 20. doi: 10.1002/dta.2981. Epub ahead of print. PMID: 33217196. https://pubmed.ncbi.nlm.nih.gov/33217196/
Paßreiter A, Thomas A, Grogna N, Delahaut P, Thevis M. First Steps toward Uncovering Gene Doping with CRISPR/Cas by Identifying SpCas9 in Plasma via HPLC-HRMS/MS. Anal Chem. 2020 Nov 25. doi: 10.1021/acs.analchem.0c04445. Epub ahead of print. PMID: 33237723. https://pubmed.ncbi.nlm.nih.gov/33237723/
Petróczi A, Backhouse SH, Boardley ID, Saugy M, Pitsiladis Y, Viret M, Ioannidis G, Ohl F, Loland S, McNamee M. ‘Clean athlete status’ cannot be certified: Calling for caution, evidence and transparency in ‘alternative’ anti-doping systems. Int J Drug Policy. 2020 Nov [26:10]3030. doi: 10.1016/j.drugpo.2020.103030. Epub ahead of print. PMID: 33250439. https://pubmed.ncbi.nlm.nih.gov/33250439/
Stoll A, Iannone M, De Gregorio G, Molaioni F, de la Torre X, Botrè F, Parr MK. Influence of Indomethacin on Steroid Metabolism: Endocrine Disruption and Confounding Effects in Urinary Steroid Profiling of Anti-Doping Analyses. Metabolites. 2020 Nov 14;10(11):463. doi: 10.3390/metabo10110463. PMID: 33202527; PMCID: PMC7698016. https://pubmed.ncbi.nlm.nih.gov/33202527/
Thevis M, Kuuranne T, Geyer H. Annual banned-substance review-analytical approaches in human sports drug testing 2019/2020. Drug Test Anal. 2020 Nov 12. doi: 10.1002/dta.2969. Epub ahead of print. PMID: 33185038. https://pubmed.ncbi.nlm.nih.gov/33185038/
Windfeld-Mathiasen J, Dalhoff KP, Andersen JT, Klemp M, Horwitz A, Horwitz H. Male fertility before and after androgen abuse. J Clin Endocrinol Metab. 2020 Nov 16:dgaa837. doi: 10.1210/clinem/dgaa837. Epub ahead of print. PMID: 33196845. https://pubmed.ncbi.nlm.nih.gov/33196845/
Yi JY, Kim M, Min H, Kim BG, Son J, Kwon OS, Sung C. New application of the CRISPR-Cas9 system for site-specific exogenous gene doping analysis. Drug Test Anal. 2020 Nov 17. doi: 10.1002/dta.2980. Epub ahead of print. PMID: 33201595. https://pubmed.ncbi.nlm.nih.gov/33201595/
If you have ideas, questions, or potentially relevant research to include, please contact Communications Director David Kumbroch at dkumbroch@cleancompetition.org.
