: Reference Materials Available for WADA Anti-Doping Laboratories | PCC - Global Anti-Doping Research Grants for Scientists

Reference Materials Available for WADA Anti-Doping Laboratories

When analyzing samples for the presence of performance enhancing substances, comparability of measurement between WADA’s 30 + worldwide laboratories is vital. Anomalies in this domain have the potential to affect not only the reputations or standing of athletes, but also the public’s trust in sport. This critical need for independent quality control and method validation within laboratory doping analysis led the PCC to fund the production of certified anti-doping reference materials for banned substance analysis, uniquely available to WADA-accredited laboratory directors. 

The materials were developed by Dr Stephen Davies and his Chemical Reference Materials team at the National Measurement Institute Australia (NMIA) as part of the 2015 PCC funded grant “The provision of steroid metabolite CRMs and internal standards in support of the Athlete Biological Passport steroid module.”

The following pure substance organic calibration standards are now available to WADA-accredited laboratory directors. NMI will provide a single unit of each material to each accredited laboratory for the cost of delivery. Lab directors wishing to receive reference materials should send a request to the PCC via Jenna Celmer at jcelmer@cleancompetition.org

 

Please note: individual labs will be responsible for applying for the appropriate import permits to facilitate the importation of reference compounds into their country.

 

All ampoules contain ~ 1 mg of material.

 

D615b 6b-Hydroxy-oral turinabol 

Ampoules in stock. Certificate of Analysis to be finalized by end of October.

 

D818b 13b, 17a-Diethyl-5b-gonane-3a, 17b-diol 

(major metabolite of norbolethone)

Ampoules in stock. Certificate of Analysis available.

 

D820b 13b, 17a-Diethyl-5a-gonane-3a, 17b-diol

(minor metabolite of norbolethone) 

Ampoules in stock. Certificate of Analysis available.

 

D825c Norbolethone (13b, 17a-Diethyl-3-keto-4-estrene)

Ampoules in stock. Certificate of Analysis available.

 

D961b Methyldienolone

Ampoules in stock. Certificate of Analysis available.

 

D1065 Formoterol fumarate

Bottled in units of 25 mg.

 

D1066 SR-9009 M6

Ampoules in stock. Certificate of Analysis available.

Human metabolite of SR9009 reported as metabolite M6 by researchers in Russia (T Sobolevsky, M Dikunets and G Rodchenkov, Recent Advances in Doping Analysis, 2015, 23, 64-69) and metabolite 5 by researchers in Belgium (L Geldof, K Deventer, K Roels, E Tudela and P Van Eenoo, Int. J. Mol. Sci., 2016, 17, 1676).

 

D1067 SR-9009 M2

Ampoules in stock. Certificate of Analysis available.

Human metabolite of SR9009 reported as metabolite M2 by researchers in Russia (T Sobolevsky, M Dikunets and G Rodchenkov, Recent Advances in Doping Analysis, 2015, 23, 64-69).

 

S003b 5b-Androstane-3a, 17b-diol-3-b-glucuronide free acid 

(metabolite of testosterone)

Ampouling not possible due to reaction with methanol. Certificate of Analysis for the bulk sample available.

 

S039 3a,5-Cyclo-5a-androstan-6b-ol-17-one 

Ampoules in stock.   Certificate of Analysis attached.

 

S043 4-Hydroxy-estr-4-en-3,17-dione 

Ampoules in stock. Certificate of Analysis to be finalized by end of October.

 

S044 17a-Methyl-4-chloro-androst-4-ene-3a, 17b-diol  

Ampoules in stock. Certificate of Analysis to be finalized by end of October.

 

PCC funded reference materials provide additional opportunities for laboratory staff and directors to confidently benchmark their analysis methods, while contributing to high-quality and accurate measurements comparable across the global suite of WADA-accredited laboratories.

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