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Research in Review: Summer 2021

It’s been a busy summer for the Partnership for Clean Competition when it comes to promoting anti-doping research. We hosted a webinar series on Anti-Doping and the Olympic/Paralympic Movement, and we also held our first virtual poster session, which left us with more than 50 anti-doping research posters to distribute.

With all that research to share, we’ve been on hiatus with our regular Research in Review articles. We’re back with a collection of research from August 2021.

if you are interested in support for your own anti-doping research, the Partnership for Clean Competition’s next pre-application deadline for grant and fellowship funding is November 1st. Pre-applications are short and straightforward, intended to ensure full applications are on-topic for the PCC. Once you have an approved pre-application, you will be invited to submit a full application by December 1st. There is no maximum or minimum amount for grant funding and timelines are flexible depending on the project. Submit your pre-application today. [1]

NOTE: The Partnership for Clean Competition aims to promote a holistic understanding of anti-doping. To move toward that goal, we’ve put together a selection of published articles from August 2021 that are relevant to clean sport. These articles may or may not stem from PCC-funded research. Posting them here should not be read as an endorsement of findings, but rather, an attempt to assemble the latest research in one place to make it easy to read and review.

Belinskaia DA, Savelieva EI, Karakashev GV, et al. Investigation of Bemethyl Biotransformation Pathways by Combination of LC-MS/HRMS and In Silico Methods. Int J Mol Sci. 2021;22(16):9021. Published 2021 Aug 21. doi:10.3390/ijms22169021 https://pubmed.ncbi.nlm.nih.gov/34445727/ [2]

Cowan DA, Moncrieffe DA. Procollagen type III amino-terminal propeptide and insulin-like growth factor I as biomarkers of growth hormone administration [published online ahead of print, 2021 Aug 21]. Drug Test Anal. 2021;10.1002/dta.3155. doi:10.1002/dta.3155 https://pubmed.ncbi.nlm.nih.gov/34418311/ [3]

Kowalczyk K, Torres-Elguera JC, Jarek A, Konopka A, Kwiatkowska D, Bulska E. In vitro metabolic studies of novel selective androgen receptor modulators and their use for doping control analysis [published online ahead of print, 2021 Aug 19]. Drug Test Anal. 2021;10.1002/dta.3151. doi:10.1002/dta.3151 https://pubmed.ncbi.nlm.nih.gov/34414676/ [4]

Knoop A, Fußhöller G, Haenelt N, et al. Mass spectrometric characterization of urinary hydrafinil metabolites for routine doping control purposes [published online ahead of print, 2021 Aug 10]. Drug Test Anal. 2021;10.1002/dta.3137. doi:10.1002/dta.3137 https://pubmed.ncbi.nlm.nih.gov/34378339/ [5]

Lee JH, Yang YJ, Min AY, et al. Screening and elucidation of fragmentations of 23 diuretics in dietary supplements using UHPLC-Q-Orbitrap. Sci Justice. 2021;61(5):451-458. doi:10.1016/j.scijus.2021.05.004 https://pubmed.ncbi.nlm.nih.gov/34482925/ [6]

Loke S, de la Torre X, Iannone M, et al. Controlled Administration of Dehydrochloromethyltestosterone in Humans: Urinary Excretion and Long-Term Detection of Metabolites for Anti-Doping Purpose [published online ahead of print, 2021 Aug 18]. J Steroid Biochem Mol Biol. 2021;105978. doi:10.1016/j.jsbmb.2021.105978 https://pubmed.ncbi.nlm.nih.gov/34418529/ [7]

Martin L, Ericsson M, Marchand A. Multiplexed detection of agents affecting erythropoiesis (AAEs) and overall strategy for optimizing initial testing procedure [published online ahead of print, 2021 Aug 2]. Drug Test Anal. 2021;10.1002/dta.3136. doi:10.1002/dta.3136 https://pubmed.ncbi.nlm.nih.gov/34342157/ [8]

Martin L, Kafi R, Zhou X, Zhang L, Ericsson M, Marchand A. Detection of recombinant erythropoietin biosimilar Jimaixin™ after administration in healthy subjects [published online ahead of print, 2021 Aug 14]. Drug Test Anal. 2021;10.1002/dta.3143. doi:10.1002/dta.3143 https://pubmed.ncbi.nlm.nih.gov/34391213/ [9]

Pokrywka A, Skrzypiec-Spring M, Krzywański J, Rynkowski M, Saugy M, Faiss R. Cases reports: Unintended anti-doping rule violation after dorzolamide use several months prior to a doping control [published online ahead of print, 2021 Aug 30]. Drug Test Anal. 2021;10.1002/dta.3156. doi:10.1002/dta.3156 https://pubmed.ncbi.nlm.nih.gov/34463045/ [10]

Rocca A, Martin L, Kuuranne T, Ericsson M, Marchand A, Leuenberger N. A fast screening method for the detection of CERA in dried blood spots [published online ahead of print, 2021 Aug 11]. Drug Test Anal. 2021;10.1002/dta.3142. doi:10.1002/dta.3142 https://pubmed.ncbi.nlm.nih.gov/34380180/ [11]

Rubio A, Görgens C, Krug O, et al. Chromatographic-mass spectrometric analysis of the urinary metabolite profile of chlorphenesin observed after dermal application of chlorphenesin-containing sunscreen [published online ahead of print, 2021 Aug 25]. Rapid Commun Mass Spectrom. 2021;e9183. doi:10.1002/rcm.9183 https://pubmed.ncbi.nlm.nih.gov/34431558/ [12]

Sobolevsky T, Ahrens B. Biotin as a masking agent in chorionic gonadotropin assays utilizing biotinylated antibodies [published online ahead of print, 2021 Aug 10]. Drug Test Anal. 2021;10.1002/dta.3141. doi:10.1002/dta.3141 https://pubmed.ncbi.nlm.nih.gov/34378342/ [13]

Solheim SA, Ringsted TK, Nordsborg NB, Dehnes Y, Levernaes MCS, Mørkeberg J. No pain, just gain: Painless, easy, and fast dried blood spot collection from fingertip and upper arm in doping control [published online ahead of print, 2021 Aug 3]. Drug Test Anal. 2021;10.1002/dta.3135. doi:10.1002/dta.3135 https://pubmed.ncbi.nlm.nih.gov/34346172/ [14]

Sugasawa T, Nakano T, Fujita SI, et al. Proof of Gene Doping in a Mouse Model with a Human Erythropoietin Gene Transferred Using an Adenoviral Vector. Genes (Basel). 2021;12(8):1249. Published 2021 Aug 16. doi:10.3390/genes12081249 https://pubmed.ncbi.nlm.nih.gov/34440425/ [15]

Thevis M, Piper T, Thomas A. Recent advances in identifying and utilizing metabolites of selected doping agents in human sports drug testing [published online ahead of print, 2021 Aug 8]. J Pharm Biomed Anal. 2021;2https://pubmed.ncbi.nlm.nih.gov/34391136/ [16]

Voss SC, Yassin M, Grivel JC, et al. Red Blood Cell derived Extracellular Vesicles during the process of autologous blood doping [published online ahead of print, 2021 Aug 28]. Drug Test Anal. 2021;10.1002/dta.3157. doi:10.1002/dta.3157 https://pubmed.ncbi.nlm.nih.gov/34453778/ [17]